Meet India's first gene-edited sheep, born in a Srinagar lab, now a healthy six-month-old
Six months ago, Professor Riyaz Ahmad Shah and his team at the Embryo Biotechnology Lab of Sher-e-Kashmir University of Agricultural Sciences and Technology (SKUAST) in Srinagar celebrated a quiet success – the birth of a Kashmir Merino, India's first gene-edited sheep.
But the team didn't rush to announce its arrival to the world – they waited, given the inherent uncertainties of scientific breakthroughs. The announcement was finally made last week after the results were validated by gene sequencing and standardised.
'This marks a new era in genetic research and has put us on the future path of transgenics in animals (inserting a foreign gene in an animal),' says Prof Shah, Dean of the Faculty of Veterinary Sciences and Animal Husbandry at SKUAST.
Gene-editing of livestock animals is a growing area of research in India with significant applications targeted at enhanced meat yield and milk production, disease resistance and resilience to impacts of climate change.
Prof Shah and his team edited the sheep's myostatin gene. 'This particular gene is a negative growth regulator. By targeting this gene, we can increase the muscle mass of a sheep by 30 per cent,' says Prof Shah.
Talking about the significance of the project, Dr Naresh Selokar, Senior Scientist, Animal Biotechnology at National Dairy Research Institute (NDRI) in Karnal, says, 'In the Indian context, this (gene-editing of sheep) is a very significant achievement, especially considering the trait (gene) that has been targeted.
'Given our population and the huge demand for meat, without gene-editing, it is impossible to change the trait of a farm animal or to make them disease resistant. This is already an easy and approved method for production globally… In India, we need to have more high-quality, disease-resistant produce through gene editing,' says Dr Selokar, who is credited with developing the first gene-edited embryo of a buffalo in 2024.
It was in 2020 that Prof Shah and his core team at SKUAST's Embryo Biotechnology Lab — Dr Suhail Magray, Dr Muneer Dar, Dr Younus Farooq, Dr Nida Handoo, Dr Syed Hilal, Dr Abrar and Dr Nafis — embarked on their ambitious project. The embryo of the sheep was first kept under laboratory conditions for some time and then transferred to a surrogate mother, before being gene-edited in July last year. To edit the myostatin gene of the sheep, the team used CRISPR-Cas9, the genome editing technology, which won Emmanuelle Charpentier and Jennifer Doudna the Nobel Prize in Chemistry that very year.
The gene-edited sheep was finally born in December last year. It's now a healthy six-month-old, housed at a farm on the Shuhama campus of the Faculty of Veterinary Science. The researchers say it weighed 3.15 kg at birth and has gained 'significant weight' since then.
'We specifically chose the myostatin gene since the goal is to increase the muscle mass of sheep. Any technological advancement in livestock and agriculture is meant to increase the farmer's income and this is an important step towards that,' says Prof Shah.
Their journey, says Dr Suhail Magray, wasn't without hurdles. 'We tried different techniques to get the desired results. We failed the first three times, before we got the breakthrough,' he says.
In a span of 15 years, SKUAST's Centre of Animal Biotechnology has taken a leap from cloning to gene-editing. In 2012, when the lab was in its infancy, it developed the world's first pashmina goat clone, which it named Noori, using the somatic cell nuclear transfer technique. The birth of Noori was seen as a breakthrough in cloning of endangered species. Noori was born on March 9, 2012 and died in March 2023 when it was 11 years old — the average age for the pashmina goat.
Their lab is now working on another gene edit — FGF5 (Fibroblast growth factor) — that will help improve the fibre quality of sheep. 'The beginning has been made,' says Dr Magray. 'Now, we can work on other genes as well that would help to make the animals disease resistant.'
With the success of their latest project, Prof Shah and his team are already preparing for the next leap — transgenics. 'We are already working on combining cloning with gene-editing to enhance the technique but our next step is to move towards transgenics,' says Prof Shah.
'Transgenics is important if we are to produce proteins of therapeutic importance – if we can, for instance, produce protein in the milk of an animal, that animal will work as a factory of proteins; animals can be pharmaceutical factories, we can have anti-cancer drugs. But for that, we have to have controlled conditions and bio-secure zones.'
A pioneer in genetics, Prof Shah was a PhD student at NDRI, Karnal, and was part of the team that's credited with the first buffalo cloning in the world. The buffalo, Samrupa, didn't survive and six months later, the team developed the second buffalo clone, 'Garima'.
Bashaarat Masood is a Special Correspondent with The Indian Express. He has been covering Jammu and Kashmir, especially the conflict-ridden Kashmir valley, for two decades. Bashaarat joined The Indian Express after completing his Masters in Mass Communication and Journalism from the University in Kashmir. He has been writing on politics, conflict and development. Bashaarat was awarded with the Ramnath Goenka Excellence in Journalism Awards in 2012 for his stories on the Pathribal fake encounter. ... Read More
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